We have a study that looks at potential drug interactions of drugs that are metabolized on the P450 enzyme pathway in humans. The link to the abstract on Medline is www.ncbi.nlm.nih.gov. If you need the full report please email us. Some chemo drugs fall into this category. This study demonstrated that I’m –Yunity® is not likely to have any drug interaction with drugs metabolized on this pathway. If you use any of the chemo drugs mentioned below that are metabolized on this pathway, chances are you have a better safety profile using concomitantly. As this study was done in human, it is difficult to say if the results would be the same in dogs without repeating a drug interaction study. However, in animal toxicity studies yunzhi was considered safe in doses up to 18g/kg in acute toxicity test1 and 6g/kg in subchronic toxicity test.
1. Tocicological research on Yun Zhi polysaccharopeptide (PSP) Jin T Y (1999) Toxicological research on Yun Zhi polyschaccharopeptide (PSP). In: Yan, Q. T. International Symposium on Traditional Chinese Medicine and Cancer: Development and Clinical Validation—Advances Research in PSP. Hong Kong Associtaion for Health Care Ltd. pp. 76-9.
2. Jiang XZ, Huang LM, Wang MM (1999) Subchronic toxicity test of polysaccharopeptide of Yunzhi (PSP). In: Yan, Q. T. International Symposium on Traditional Chinese Medicine and Cancer: Development and Clinical Validation—Advance Research in PSP. Hong Kong Association for Health Care Ltd. pp. 272-84.